22 "But if he stabbed him suddenly without enmity, or hurled anything on him without lying in wait,
23 or used a stone, by which a man may die, and without seeing him cast it upon him, so that he died, though he was not his enemy, and did not seek his harm;
24 then the congregation shall judge between the manslayer and the avenger of blood, in accordance with these ordinances;
25 and the congregation shall rescue the manslayer from the hand of the avenger of blood, and the congregation shall restore him to his city of refuge, to which he had fled, and he shall live in it until the death of the high priest who was anointed with the holy oil.
26 But if the manslayer shall at any time go beyond the bounds of his city of refuge to which he fled,
27 and the avenger of blood finds him outside the bounds of his city of refuge, and the avenger of blood slays the manslayer, he shall not be guilty of blood.
28 For the man must remain in his city of refuge until the death of the high priest; but after the death of the high priest the manslayer may return to the land of his possession.
29 "And these things shall be for a statute and ordinance to you throughout your generations in all your dwellings.
30 If any one kills a person, the murderer shall be put to death on the evidence of witnesses; but no person shall be put to death on the testimony of one witness.
31 Moreover you shall accept no ransom for the life of a murderer, who is guilty of death; but he shall be put to death.
32 And you shall accept no ransom for him who has fled to his city of refuge, that he may return to dwell in the land before the death of the high priest.
33 You shall not thus pollute the land in which you live; for blood pollutes the land, and no expiation can be made for the land, for the blood that is shed in it, except by the blood of him who shed it.
34 You shall not defile the land in which you live, in the midst of which I dwell; for I, YHVH, dwell in the midst of the people of Israel."
To defile the land with blood is to destroy life. “The blood thereof is the life thereof.” We would not be worthy of the indwelling of YHVH or Christos if we are destroyers of life. But, in the sense used here, it is referring to the life of the Spirit. And so, it is the spiritual life which we must cherish and honor.